sa1621sa481sa41</head><body><p>From SARS-COV-1: Through similar assays, the region PL2pro−NAB−βSM was found to interact with Nsp4 as well as Nsp12 (Pan et al., 2008). The SARS-CoV PL2pro was further shown to bind ORF7a and Nsp6 by using proteomics analysis (Neuman et al., 2008). [PMID:29128390] </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re49"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:29128390" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:2697049" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_csa15"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa4" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa15_in_0" /><qual:input qual:qualitativeSpecies="sa14" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa15_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="csa15" qual:transitionEffect="assignmentLevel" qual:id="tr_csa15_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>sa4</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa14</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>[PMID: 32353859] </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re23"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:2697049" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_csa5"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa2" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa5_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="csa5" qual:transitionEffect="assignmentLevel" qual:id="tr_csa5_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>csa2</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>IDE can be found in cytosol, extracellular region or secreted, mitochondrion, nucleus, peroxisome and plasma Membrane [https://www.uniprot.org/uniprot/P14735#subcellular_location] </p> </body></html></notes></qual:transition><qual:transition qual:id="tr_csa12"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa4" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa12_in_0" /><qual:input 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xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>Nsp6 binds ATP5MG [PMID: 32353859] </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#CDMT00066"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:2697049" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_csa13"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa14" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa13_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="csa13" qual:transitionEffect="assignmentLevel" qual:id="tr_csa13_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math 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/></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><or /><apply><and /><apply><eq /><ci>sa4</ci><cn type="integer">1</cn></apply><apply><eq /><ci>csa24</ci><cn type="integer">1</cn></apply></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>Nsp6 binds TIMM9, 10, 10B and 29. 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<rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_csa40"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa48" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa40_in_0" /><qual:input qual:qualitativeSpecies="csa41" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa40_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="csa40" qual:transitionEffect="assignmentLevel" qual:id="tr_csa40_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>sa48</ci><cn type="integer">1</cn></apply><apply><eq /><ci>csa41</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html 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rdf:resource="urn:miriam:taxonomy:2697049" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_csa49"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa191" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa49_in_0" /><qual:input qual:qualitativeSpecies="sa200" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa49_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="csa49" qual:transitionEffect="assignmentLevel" qual:id="tr_csa49_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>sa191</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa200</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>[PMID: 32353859] </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re57"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_csa33"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa30" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa33_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="csa33" qual:transitionEffect="assignmentLevel" qual:id="tr_csa33_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>csa30</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re80"> <bqmodel:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:uniprot:Q15904" /> </rdf:Bag> </bqmodel:is> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_csa50"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa223" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa50_in_0" /><qual:input qual:qualitativeSpecies="sa188" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa50_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="csa50" qual:transitionEffect="assignmentLevel" qual:id="tr_csa50_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>sa223</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa188</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>[PMID: 32353859] </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re60"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_csa18"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa48" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa18_in_0" /><qual:input qual:qualitativeSpecies="sa53" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa18_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="csa18" qual:transitionEffect="assignmentLevel" qual:id="tr_csa18_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>sa48</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa53</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>Nsp6 binds SIGMAR1 [PMID: 32353859] </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re27"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:2697049" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_csa2"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa4" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa2_in_0" /><qual:input qual:qualitativeSpecies="sa8" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa2_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="csa2" qual:transitionEffect="assignmentLevel" qual:id="tr_csa2_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>sa4</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa8</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>Nsp6 binds IDE [PMID: 32353859] </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re8"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:2697049" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_csa92"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa18" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa92_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="csa92" qual:transitionEffect="assignmentLevel" qual:id="tr_csa92_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>csa18</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re75"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:10406945" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_csa93"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa15" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa93_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="csa93" qual:transitionEffect="assignmentLevel" qual:id="tr_csa93_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>csa15</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms></qual:transition><qual:transition qual:id="tr_sa3"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa220" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa3_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa3" qual:transitionEffect="assignmentLevel" qual:id="tr_sa3_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa220</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re1"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa4"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa3" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa4_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa4" qual:transitionEffect="assignmentLevel" qual:id="tr_sa4_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa3</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re2"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa47"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa218" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa47_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa47" qual:transitionEffect="assignmentLevel" qual:id="tr_sa47_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa218</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#CDMT00054"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa48"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa47" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa48_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa48" qual:transitionEffect="assignmentLevel" qual:id="tr_sa48_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa47</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#CDMT00057"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa154"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa8" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa154_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa154" qual:transitionEffect="assignmentLevel" qual:id="tr_sa154_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa8</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>To confirm the extracellular occurrence of IDE in vivo, we identified intact IDE in human cerebrospinal fluid of both normal and Alzheimer subjects. [DOI:10.1074/jbc.273.49.32730] IDE can be found in cytosol, extracellular region or secreted, mitochondrion, nucleus, peroxisome and plasma membrane [https://www.uniprot.org/uniprot/P14735#subcellular_location] </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re40"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:9830016" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa160"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa219" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa160_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa160" qual:transitionEffect="assignmentLevel" qual:id="tr_sa160_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa219</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re43"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa162"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa160" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa162_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa162" qual:transitionEffect="assignmentLevel" qual:id="tr_sa162_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa160</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re45"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa164"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa39" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa164_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa164" qual:transitionEffect="assignmentLevel" qual:id="tr_sa164_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>csa39</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>From SARS-COV-1: Co-expression of Nsp3, Nsp4, and Nsp6 can induce DMV formation in SARS-CoV-infected cells but the same result was not observed when Nsp3 lacking its C-terminal third (residues 1319–1922) was co-expressed with Nsp4 and Nsp6 (Angelini et al., 2013). [PMID:29128390] doi:10.1101/2020.03.22.002386 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re64"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:2697049" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa218"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa47" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa218_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa218" qual:transitionEffect="assignmentLevel" qual:id="tr_sa218_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa47</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re32"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa219"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa160" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa219_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa219" qual:transitionEffect="assignmentLevel" qual:id="tr_sa219_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa160</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re44"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa220"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa3" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa220_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa220" qual:transitionEffect="assignmentLevel" qual:id="tr_sa220_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa3</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re24"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32353859" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa224"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa9" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa224_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa224" qual:transitionEffect="assignmentLevel" qual:id="tr_sa224_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa9</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re71"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:14517331" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa225"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa8" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa225_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa225" qual:transitionEffect="assignmentLevel" qual:id="tr_sa225_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa8</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re72"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:10116" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa226"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa53" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa226_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa226" qual:transitionEffect="assignmentLevel" qual:id="tr_sa226_out" 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xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa53</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re74"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:10406945" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa230"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa14" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa230_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa230" qual:transitionEffect="assignmentLevel" qual:id="tr_sa230_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa14</ci><cn 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